Methanesulfonic anhydride → HCID 86743798, compound

HRID 1164979Notes

Reaction equation

HRID 1164979 reaction equation
[CH2:1]([N:3]([CH2:14][CH3:15])[CH2:4][CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=1)[CH3:2].[CH3:16][S:17]([O:20]S(C)(=O)=O)(=[O:19])=[O:18]>C(#N)C>[CH3:16][S:17]([OH:20])(=[O:19])=[O:18].[CH2:14]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([NH:13][S:17]([CH3:16])(=[O:19])=[O:18])=[CH:11][CH:12]=1)[CH3:15]

Participants

4

Reactant 2

HCID 81560Methanesulfonic anhydrideHCID 4189324-(2-(Diethylamino)ethoxy)aniline

Product 1

HCID 86743798HCID 86743798, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of 2.8 g (12.4 mmol) of 4-[2-(diethylamino)ethoxy]benzenamine dissolved in 30 mL of acetonitrile cooled to 0° C. add 2.6 g (15 mmol) of methanesulfonic anhydride. Stir the reaction mixture for 4 h at ambient temperature. Remove the solvent in vacuo and recrystallize the residue from acetonitrile/ethyl acetate to obtain the title compound.

Workup

  1. customRemove the solvent in vacuo
  2. customrecrystallize the residue from acetonitrile/ethyl acetate

Sources & evidence

ORD record
ord-dc11c738a98840e680c78e5626feedc3
Source dataset
uspto-grants-1990_03
Patent number
US04906634

Reaction notes

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