2-Chloroethanol → HCID 12829775, compound

Temperature

0 °C

Dihydropyran (85 g, 1.01 moles) and 0.2 mL of concentrated HCl were added to a 500 mL 3-necked round-bottomed flask equipped with a magnetic stirrer, a thermocouple, a reflux condenser and a nitrogen bubbler. The mixture was cooled to 0° C., and then 2-chloro-ethan-1-ol (80.5 g, 1.01 moles) was added dropwise at a rate sufficient to maintain the temperature below 10° C. After the addition was complete (about 2 hr.), the mixture was allowed to warm to room temperature and stirred for 1 hr. The clear yellow solution was distilled under vacuum.

1. customequipped with a magnetic stirrer
2. temperatureto maintain the temperature below 10° C
3. additionAfter the addition
4. custom(about 2 hr.)
5. temperatureto warm to room temperature
6. distillationThe clear yellow solution was distilled under vacuum

ORD record

ord-8aec98de52b84db292c88a16c0ff3f7f

Source dataset

uspto-grants-1990_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04906713