5-Methylindole → 2-(5-methyl-1H-indol-3-yl)-2-oxoacetyl chloride

HRID 1165079Notes

Reaction equation

HRID 1165079 reaction equation
[C:1](Cl)(=[O:5])[C:2]([Cl:4])=[O:3].[CH3:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][CH:12]=[CH:11]2>CCOCC>[CH3:7][C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][CH:12]=[C:11]2[C:1](=[O:5])[C:2]([Cl:4])=[O:3]

Participants

4

Reactant 2

HCID 119785-MethylindoleHCID 65578Oxalyl chloride

Product 1

HCID 121874182-(5-methyl-1H-indol-3-yl)-2-oxoacetyl chloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Oxalyl chloride (0.76 ml) was slowly added to a stirred solution of 1 g of 5-methylindole in 20 ml of anhydrous ether at 0° C. The precipitate which formed was filtered off and dried at 80° C. to give 5-methyl-3-indolylglyoxylyl chloride.

Workup

  1. customThe precipitate which formed
  2. filtrationwas filtered off
  3. customdried at 80° C.

Sources & evidence

ORD record
ord-4d0502282b854029b6e941e39e0a32d6
Source dataset
uspto-grants-1990_03
Patent number
US04906755

Reaction notes

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