HCID 178441074, compound → Hwa 131

HRID 1165132Notes

Reaction equation

HRID 1165132 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([CH:19]=[C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])[C:21]=1[OH:22])[C:8](=O)[CH2:9][S:10][C:11]1[NH:12][N:13]=[CH:14][C:15](=[O:17])[N:16]=1)([CH3:4])([CH3:3])[CH3:2]>O1CCCC1.Cl>[C:1]([C:5]1[CH:6]=[C:7]([C:8]2[N:12]3[N:13]=[CH:14][C:15](=[O:17])[N:16]=[C:11]3[S:10][CH:9]=2)[CH:19]=[C:20]([C:23]([CH3:26])([CH3:25])[CH3:24])[C:21]=1[OH:22])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 178441074HCID 178441074, compound

Product 1

HCID 159492Hwa 131

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8028TetrahydrofuranSolvent

Procedure

3.7 g (0.01 mol) of 3-[(3,5-di-tert.butyl-4-hydroxyphenacyl)-thio]-2H-1,2,4-triazin-5-one from step (b1) were stirred for 36 hours at room temperature in a mixture of 60 ml of tetrahydrofuran and 50 ml of 2N hydrochloric acid. The cyclocondensation product which slowly precipitated out was filtered off and recrystallized once to three times from tetrachydrofuran/ethanol (3:2).

Workup

  1. customThe cyclocondensation product which slowly precipitated out
  2. filtrationwas filtered off
  3. customrecrystallized once to three times from tetrachydrofuran/ethanol (3:2)

Sources & evidence

ORD record
ord-f123162694b94100a8645f93e032f43b
Source dataset
uspto-grants-1990_03
Patent number
US04908364

Reaction notes

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