反应详情

A solution of 2-bromo-1-[3-(methoxymethyl)-4-(phenylmethoxy)phenyl]ethanone (2.0 g), dibenzylamine (1.2 g) and DEA (0.8 g) in THF (30 ml) was allowed to stand at room temperature for 18 h, filtered and evaporated. The residual oil was dissolved in ethanol (20 ml) and treated portionwise with sodium borohydride (0.23 g), under nitrogen. The mixture was stirred at room temperature for 1 h, treated with methanol (20 ml), and evaporated. The residue was purified by FCC eluting with CX-ER (3:1) to give the title compound as an off-white solid (2.3 g), m.p. 52°-57°, t.l.c. (CX-ER 1:1) Rf 0.5

1. filtrationfiltered
2. customevaporated
3. dissolutionThe residual oil was dissolved in ethanol (20 ml)
4. additiontreated portionwise with sodium borohydride (0.23 g), under nitrogen
5. additiontreated with methanol (20 ml)
6. customevaporated
7. customThe residue was purified by FCC
8. washeluting with CX-ER (3:1)