Hydroxyphenylacetic acid → Ethyl 4-hydroxyphenylacetate

HRID 1165397Notes

Reaction equation

HRID 1165397 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH2:17](O)[CH3:18]>>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH2:17][CH3:18])=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 127Hydroxyphenylacetic acidHCID 702EthanolHCID 1118Sulfuric Acid

Product 1

HCID 28310Ethyl 4-hydroxyphenylacetate

Procedure

4-Hydroxyphenylacetic acid (50.0 g) is dissolved in ethanol (400 ml) and thereto is added conc. sulfuric acid (0.5 ml). The mixture is refluxed with stirring, and ethanol is distilled off to give ethyl 4-hydroxyphenylacetate (60 g).

Workup

  1. temperatureThe mixture is refluxed
  2. distillationethanol is distilled off

Sources & evidence

ORD record
ord-675e0c6ba0dc454a96f5fe11192c2d8a
Source dataset
uspto-grants-1990_03
Patent number
US04909957

Reaction notes

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