Hydrochloric Acid → 3,4-Dimethoxy-4'-phenylbenzophenone

HRID 1165470노트

반응식

HRID 1165470 반응식
[C:1]1([O:9][CH3:10])[C:2](=[CH:5][CH:6]=[CH:7][CH:8]=1)[O:3][CH3:4].[Cl-].[Al+3].[Cl-].[Cl-].[C:15]1([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:20]=[CH:19][C:18]([C:21](Cl)=[O:22])=[CH:17][CH:16]=1.Cl>C(Cl)Cl>[CH3:4][O:3][C:2]1[CH:5]=[C:6]([CH:7]=[CH:8][C:1]=1[O:9][CH3:10])[C:21]([C:18]1[CH:19]=[CH:20][C:15]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)=[CH:16][CH:17]=1)=[O:22]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7043VeratroleHCID 841514-Phenylbenzoyl chlorideHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 22887323,4-Dimethoxy-4'-phenylbenzophenone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

300 g of veratrole was added dropwise over a period of 30 minutes to a suspension of 300 g of aluminum chloride in 300 ml of methylene chloride, taking care that the internal temperature did not exceed 30° C. Then, 450 g of biphenyl-4-carboxylic acid chloride were added in portions over a period of 30 minutes, while stirring and cooling (internal temperature 20°-25° C.). The resulting mixture was stirred for 4 hours at room temperature and was then poured into a mixture of 2 kg of ice/500 ml of concentrated hydrochloric acid. After the organic phase had been separated, the aqueous phase was extracted twice more with methylene chloride.

후처리

  1. customdid not exceed 30° C
  2. temperaturecooling (internal temperature 20°-25° C.)
  3. stirringThe resulting mixture was stirred for 4 hours at room temperature
  4. customAfter the organic phase had been separated
  5. extractionthe aqueous phase was extracted twice more with methylene chloride

출처 및 근거

ORD 기록
ord-9bcf49f66e654c7a99a31ba7a70c2bf0
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04910200

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