反应详情

300 g of veratrole was added dropwise over a period of 30 minutes to a suspension of 300 g of aluminum chloride in 300 ml of methylene chloride, taking care that the internal temperature did not exceed 30° C. Then, 450 g of biphenyl-4-carboxylic acid chloride were added in portions over a period of 30 minutes, while stirring and cooling (internal temperature 20°-25° C.). The resulting mixture was stirred for 4 hours at room temperature and was then poured into a mixture of 2 kg of ice/500 ml of concentrated hydrochloric acid. After the organic phase had been separated, the aqueous phase was extracted twice more with methylene chloride.

1. customdid not exceed 30° C
2. temperaturecooling (internal temperature 20°-25° C.)
3. stirringThe resulting mixture was stirred for 4 hours at room temperature
4. customAfter the organic phase had been separated
5. extractionthe aqueous phase was extracted twice more with methylene chloride