2-Amino-2-methyl-1,3-propanediol → HCID 14770227, compound

HRID 1165645Notes

Reaction equation

HRID 1165645 reaction equation
[CH:1]1[C:9]2[C:8]3[C:10]([CH:18]=O)=[C:11]4[C:16](=[CH:17][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][CH:2]=1)[CH:15]=[CH:14][CH:13]=[CH:12]4.[NH2:20][C:21]([CH3:26])([CH2:24][OH:25])[CH2:22][OH:23]>CCO.CCOCC>[CH:1]1[C:9]2[C:8]3[C:10]([CH2:18][NH:20][C:21]([CH3:26])([CH2:24][OH:25])[CH2:22][OH:23])=[C:11]4[C:16](=[CH:17][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][CH:2]=1)[CH:15]=[CH:14][CH:13]=[CH:12]4

Participants

4

Reactant 2

HCID 15312-Amino-2-methyl-1,3-propanediolHCID 14770208HCID 14770208, compound

Product 1

HCID 14770227HCID 14770227, compoundYield 68.8%

Reagents, catalysts & solvents 1

HCID 21585056Diethyl ether ethanolSolvent

Procedure

Using the procedure outlined in Example 1, benzo[b]naphtho[2,3-d]furan-11-carbaldehyde (2B) and 2-amino-2-methyl-1,3-propanediol (Aldrich) gave a 68.8% yield of 2-[[(benzo[b]naphtho[2,3-d]furan-11-yl)methyl]amino]-2-methyl-1,3-propanediol methanesuylfonate, mp 219°-220° (dec), (C,H,N,S), (EtOH/Et2O).

Sources & evidence

ORD record
ord-f13d8024635e49329640aa7217dcc88a
Source dataset
uspto-grants-1990_03
Patent number
US04910218

Reaction notes

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