2-Amino-2-methyl-1,3-propanediol → HCID 20065843, compound

HRID 1165653Notes

Reaction equation

HRID 1165653 reaction equation
[CH:1]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:2]=1[C:3]1[C:11]([CH:12]=[CH:13]2)=[C:10]([CH:18]=O)[C:6]2[S:7][CH:8]=[CH:9][C:5]=2[CH:4]=1.[NH2:20][C:21]([CH3:26])([CH2:24][OH:25])[CH2:22][OH:23]>CCO.CCOCC>[CH3:26][C:21]([NH:20][CH2:18][C:10]1[C:6]2[S:7][CH:8]=[CH:9][C:5]=2[CH:4]=[C:3]2[C:11]=1[CH:12]=[CH:13][C:14]1[C:2]2=[CH:1][CH:17]=[CH:16][CH:15]=1)([CH2:24][OH:25])[CH2:22][OH:23]

Participants

4

Reactant 2

HCID 15312-Amino-2-methyl-1,3-propanediolHCID 20065864HCID 20065864, compound

Product 1

HCID 20065843HCID 20065843, compoundYield 71.2%

Reagents, catalysts & solvents 1

HCID 21585056Diethyl ether ethanolSolvent

Procedure

Using the procedure outlined in Example 1, phenanthro[2,3-b]thiophene-7-carbaldehyde (24A) and 2-amino-2-methyl-1,3-propanediol (Aldrich) gave a 71.2% yield of 2-methyl-2-[[(phenanthro[2,3-b]thiophen-7-yl)methyl]amino]-1,3-propanediol methanesulsonate, mp 212°-215° (EtOH/Et2O), (C,H,N,S).

Sources & evidence

ORD record
ord-c088ae06718e436589eb1f22bab4df19
Source dataset
uspto-grants-1990_03
Patent number
US04910218

Reaction notes

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