反应详情

N-acetyl-3-(2,5-difluorophenyl)imidazolidine-2,4-dione (2.1 g, 8.2 mmol), 4-methylbenzaldehyde (1.05 g, 8.7 mmol) and triethylamine (1.7 g, 16.5 mmol) were heated under reflux in DMF (20 mL) for 4 hours. The solution was cooled diluted with water and extracted with ethyl acetate (3×). The combined extracts were washed with brine (saturated), dried (over MgSO4), filtered and concentrated to give 2.3 grams of 5-(4-methylbenzylidene)-3-(2,5-difluorophenyl)imidazolidine-2,4-dione, m.p. 218°-224° C.

1. temperatureThe solution was cooled
2. extractionextracted with ethyl acetate (3×)
3. washThe combined extracts were washed with brine (saturated)
4. dry with materialdried (over MgSO4)
5. filtrationfiltered
6. concentrationconcentrated