HCID 14837973, compound → HCID 178448714, compound

HRID 1165774Notes

Reaction equation

HRID 1165774 reaction equation
[C:1]([NH:4][C:5](=S)[NH:6][NH:7][C:8]1[N:13]([CH2:14][CH2:15][CH2:16][CH3:17])[C:12](=[O:18])[N:11]([CH2:19][CH2:20][CH3:21])[C:10](=[O:22])[CH:9]=1)(=[O:3])[CH3:2]>CN(C)C=O>[C:1]([NH:4][C:5]1[C:9]2[C:10](=[O:22])[N:11]([CH2:19][CH2:20][CH3:21])[C:12](=[O:18])[N:13]([CH2:14][CH2:15][CH2:16][CH3:17])[C:8]=2[NH:7][N:6]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 14837973HCID 14837973, compound

Product 1

HCID 178448714HCID 178448714, compoundYield 81.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

6-(4-Acetylthiosemicarbazido)-1-butyl-3-propylpyrimidine-2,4(1H,3H)-dione (6.0 g) was heated in dimethylformamide (DMF) (60 ml) at 110°-120° C. for 60 hours. The reaction mixture was concentrated to dryness to give a crystalline product, which were recrystallized from aqueous methanol to afford colorless crystals (4.4 g, 61%),

Workup

  1. concentrationThe reaction mixture was concentrated to dryness
  2. customto give a crystalline product, which
  3. customwere recrystallized from aqueous methanol

Sources & evidence

ORD record
ord-be9a0b8467a04cc4b8c6353a716e4f7a
Source dataset
uspto-grants-1990_03
Patent number
US04912104

Reaction notes

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