Hydrazine hydrate (1:1) → HCID 178462867, compound

HRID 1165778Notes

Reaction equation

HRID 1165778 reaction equation
Cl[C:2]1[N:7]([CH2:8][CH3:9])[C:6](=[O:10])[N:5]([CH2:11][CH3:12])[C:4](=O)[C:3]=1[C:14]#[N:15].[OH2:16].[NH2:17][NH2:18]>CO>[NH2:15][C:14]1[C:3]2[C:2](=[O:16])[N:7]([CH2:8][CH3:9])[C:6](=[O:10])[N:5]([CH2:11][CH3:12])[C:4]=2[NH:18][N:17]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13556945HCID 13556945, compound

Product 1

HCID 178462867HCID 178462867, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 6-chloro-5-cyano-1,3-diethylpyrimidine-2,4(1H, 3H)-dione(5 g) and hydrazine monohydrate (2.2 ml) in methanol (220 ml) was stirred for 10 minutes at room temperature. The reaction mixture was concentrated to dryness under reduced pressure, and the concentrate was crystallized from aqueous methanol to obtain colorless needles(4.3 g), m.p. 246°-248° C.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness under reduced pressure
  2. customthe concentrate was crystallized from aqueous methanol

Sources & evidence

ORD record
ord-88527a444fad4b70b68fc90a92f9cedd
Source dataset
uspto-grants-1990_03
Patent number
US04912104

Reaction notes

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