Chloride → 2-(4-Chlorobenzoylamino)-4,5-dimethoxybenzamide

HRID 1166149Notes

Reaction equation

HRID 1166149 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Cl:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1.[Cl-]>C(N(CC)CC)C>[Cl:15][C:16]1[CH:24]=[CH:23][C:19]([C:20]([NH:1][C:2]2[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:3]=2[C:4]([NH2:6])=[O:5])=[O:21])=[CH:18][CH:17]=1

Participants

5

Reactant 3

HCID 312ChlorideHCID 85014-Chlorobenzoyl chlorideHCID 108672362-Amino-4,5-dimethoxybenzamide

Product 1

HCID 229974052-(4-Chlorobenzoylamino)-4,5-dimethoxybenzamide

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A mixture of 13.7 g of 2-amino-4,5-dimethoxybenzamide, 8.1 g of triethylamine, 13.8 g of 4-chlorobenzoyl chloride and 300 ml of methylene. chloride was stirred for 2 h without cooling. The precipitate was filtered off with suction, stirred with water, filtered off with suction and dried under reduced pressure. Yield: 22.5 g. M.p.: 243° C.

Workup

  1. temperaturewithout cooling
  2. filtrationThe precipitate was filtered off with suction
  3. filtrationfiltered off with suction
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-613e2bffac8c4b2e949d650e7fa53372
Source dataset
uspto-grants-2003_09
Patent number
US06613772B1

Reaction notes

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