反应详情

温度

0 °C

To a stirred solution of 3-(10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)-1-propanol (1.44 g, 0.0057 mol, prepared similarly as described in example 2) and triethylamine (1.46 g, 0.014 mol) in toluene (40 ml) at 0° C., methanesulfonyl chloride (0.88 ml, 0.011 mol) was added dropwise over 10 minutes. The resulting mixture was stirred at 0° C. for 1.5 h. Toluene (50 ml) and water (100 ml) were added, and the phases were separated. The aqueous phase was extracted with toluene (50 ml), and the combined organic phases were washed with brine (2×100 ml), dried (MgSO4) and concentrated in vacuo. The residue was dissolved in acetonitrile (20 ml) and 3-piperidinecarboxamide (1.09 g, 0.0085 mol) and potassium carbonate (1.76 g, 0.013 mol) were added. The mixture was heated at reflux temperature for 4 h, and stirred at room temperature for 40 h. Water (20 ml) was added, and the product was extracted with ethyl acetate (2×20 ml). The combined organic extracts were washed with brine (2×20 ml), dried (MgSO4) and concentrated in vacuo. Water (20 ml) and concentrated hydrochloric acid (3.0 ml) were added, and the mixture was extracted with dichloromethane (2×20 ml), dried (MgSO4) and concentrated in vacuo. The residue was redissolved in a mixture of warm ethyl acetate (10 ml) and methanol (1.0 ml), and after standing for 5 h at room temperature, a precipitate was filtered off and dried, affording 1.56 g (64%) of the title compound.

1. customat 0° C.
2. customthe phases were separated
3. extractionThe aqueous phase was extracted with toluene (50 ml)
4. washthe combined organic phases were washed with brine (2×100 ml)
5. dry with materialdried (MgSO4)
6. concentrationconcentrated in vacuo
7. dissolutionThe residue was dissolved in acetonitrile (20 ml)
8. temperatureThe mixture was heated
9. temperatureat reflux temperature for 4 h
10. stirringstirred at room temperature for 40 h
11. extractionthe product was extracted with ethyl acetate (2×20 ml)
12. washThe combined organic extracts were washed with brine (2×20 ml)
13. dry with materialdried (MgSO4)
14. concentrationconcentrated in vacuo
15. additionWater (20 ml) and concentrated hydrochloric acid (3.0 ml) were added
16. extractionthe mixture was extracted with dichloromethane (2×20 ml)
17. dry with materialdried (MgSO4)
18. concentrationconcentrated in vacuo
19. dissolutionThe residue was redissolved in a mixture of warm ethyl acetate (10 ml) and methanol (1.0 ml)
20. waitafter standing for 5 h at room temperature
21. filtrationa precipitate was filtered off
22. customdried