反应详情

To a stirring boiling solution of sulfur (3.7 g) in 12% aqueous NaOH (50 mL) was added a solution of 4-nitro-1-methylnaphthalene (8 g) in ethanol (50 mL). After refluxing the solution for one hour, the reaction was diluted with 500 mL of ethyl acetate and washed with water and brine, dried over MgSO4, and concentrated. The product was purified via silica gel column chromatography using ethyl acetate:hexane (5:95 to 10:90). The product (2.54 g, 34%) was stored at −78° C.

1. temperatureAfter refluxing the solution for one hour
2. washwashed with water and brine
3. dry with materialdried over MgSO4
4. concentrationconcentrated
5. customThe product was purified via silica gel column chromatography
6. customwas stored at −78° C.