Benzo(B)Thiophene → 6314-41-6

HRID 1166913Notes

Reaction equation

HRID 1166913 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2.[Li]C(C)(C)C.[Cl:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=1>C1COCC1>[S:1]1[C:5]([CH:20]([OH:21])[C:19]2[CH:22]=[CH:23][C:16]([Cl:15])=[CH:17][CH:18]=2)=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 7221Benzo(B)ThiopheneHCID 77264-ChlorobenzaldehydeHCID 178418306HCID 178418306, compound

Product 1

HCID 2370726314-41-6

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

a-(2-benzo[b]thienyl)-4-chlorobenzyl alcohol was prepared by the method of Example 40A with benzo[b]thiophene (7.5 mmoles, 1.0 g), t-BuLi (1.7 m, 9.7 mmoles, 5.7 ml), 4-chlorobenzaldehyde (9.7 mmoles, 1.4 g) and THF (20 ml). The crude material (2.45 g) was taken forward without further purification.

Workup

  1. customThe crude material (2.45 g) was taken forward without further purification

Sources & evidence

ORD record
ord-16d9f00fc21d4d6f92a6da709cbaed64
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

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