Iodoethane → 2-Ethylbenzofuran

HRID 1166927Notes

Reaction equation

HRID 1166927 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2.[Li][C:11](C)(C)[CH3:12].ICC>C1COCC1>[CH2:11]([C:5]1[O:1][C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[CH:4]=1)[CH3:12]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 9223BenzofuranHCID 178418306HCID 178418306, compound

Product 1

HCID 765822-Ethylbenzofuran

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Ethylbenzo[b]furan was prepared by the method of example 40A with benzo[b]furan (7.3 mmols), 0.86 g) t-BuLi (1.7 m, 9.4 mmols) iodoethane (4 mmols, 0.9 mls) and THF (15 ml). 1.0 g (95%) of a yellow liquid was isolated.

Sources & evidence

ORD record
ord-5b3c0aa2459c41efa590b17b168410d4
Source dataset
uspto-grants-2003_09
Patent number
US06613804B2

Reaction notes

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