反应详情

A mixture of dimethylamine hydrochloride (0.18 g), 4-bromomethyl-7-methoxycoumarin (0.30 g), potassium carbonate (0.5 g) and dichloromethane (10 ml) was stirred at room temperature for 2 days. The solid was filtered off and the filtrate concentrated. The residue was purified by chromatography on silica gel (eluent 5% methanol in dichloromethane), then crystallised from methanol to give the title compound as a white solid (0.145 g).

1. filtrationThe solid was filtered off
2. concentrationthe filtrate concentrated
3. customThe residue was purified by chromatography on silica gel (eluent 5% methanol in dichloromethane)
4. customcrystallised from methanol