Hydrogen Peroxide → HCID 22996259, compound

HRID 1167361Notes

Reaction equation

HRID 1167361 reaction equation
Cl.[NH2:2][C:3]([CH3:22])([CH3:21])[CH2:4][CH2:5][C:6]1[CH:20]=[CH:19][C:9]([O:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=2)=[CH:8][CH:7]=1.C(=O)([O-])[O-:24].[K+].[K+].OO.O>CS(C)=O>[NH2:2][C:3]([CH3:22])([CH3:21])[CH2:4][CH2:5][C:6]1[CH:20]=[CH:19][C:9]([O:10][C:11]2[CH:18]=[CH:17][C:14]([C:15]([NH2:16])=[O:24])=[CH:13][CH:12]=2)=[CH:8][CH:7]=1

Participants

6

Reactant 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 11430Potassium CarbonateHCID 22996260HCID 22996260, compound

Product 1

HCID 22996259HCID 22996259, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

4-(4-(3-Amino-3-methylbutyl)phenoxy)benzonitrile hydrochloride (1.04 g, 32.8 mmol) was dissolved in DMSO (30 ml) and treated with potassium carbonate (0.68g, 49.2 mmol, 1.5 eq.) with stirring. After 10 minutes, hydrogen peroxide (7 ml, 30% aqueous solution) was added dropwise slowly. The mixture was allowed to stir for 16 hours and then added to 300 ml of water, causing a white precipitate. The material was filtered and dried to give a white solid (908mg, 93%). NMR, MS.

Workup

  1. stirringto stir for 16 hours
  2. filtrationThe material was filtered
  3. customdried

Sources & evidence

ORD record
ord-0f0695a7e573487d95d9a2aae813e309
Source dataset
uspto-grants-2003_09
Patent number
US06617347B1

Reaction notes

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