Ethanol → L-Ascorbic Acid

HRID 1167405Notes

Reaction equation

HRID 1167405 reaction equation
C(O)C.[Na].[CH2:5]([OH:17])[C@H:6]([OH:16])[C@@H:7](O)[C@H:8]([OH:14])[C:9]([C:11]([OH:13])=[O:12])=[O:10]>CC(C)=O>[O:12]=[C:11]1[O:13][C@H:7]([C@H:6]([CH2:5][OH:17])[OH:16])[C:8]([OH:14])=[C:9]1[OH:10]

Participants

5

Reactant 3

HCID 702EthanolHCID 1024242-keto-L-Gulonic acidHCID 5360545Sodium

Product 1

HCID 54670067L-Ascorbic Acid

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

JP-AS 58-177986 describes a process which comprises the addition of ethanol and acetone to the sodium salt of 2-keto-L-gulonic acid, neutralization with hydrochloric acid, separation of the precipitated sodium chloride by filtration and subsequently the keeping of the reaction mixture at temperatures in the range from 25° C. to 75° C., whereby L-ascorbic acid is obtained.

Workup

  1. customwith hydrochloric acid, separation of the precipitated sodium chloride
  2. filtrationby filtration
  3. customkeeping of the reaction mixture at temperatures in the range from 25° C. to 75° C.

Sources & evidence

ORD record
ord-834971ba34254d8da2fe90b2daf1066a
Source dataset
uspto-grants-2003_09
Patent number
US06617463B2

Reaction notes

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