Potassium Carbonate → HCID 69982183, compound

HRID 1167440Notes

Reaction equation

HRID 1167440 reaction equation
[Cl-:1].C([O:5][C@@H:6]([CH2:36][N+:37]([CH3:40])([CH3:39])[CH3:38])[CH2:7][C:8]([N:10]1[CH2:15][CH2:14][N:13]([C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:26][C@H:25]([CH2:27][O:28][C:29]4[CH:33]=[CH:32][O:31][N:30]=4)[O:24][C:23]3=[O:34])=[CH:18][C:17]=2[F:35])[CH2:12][CH2:11]1)=[O:9])(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[Cl-:1].[OH:5][C@@H:6]([CH2:36][N+:37]([CH3:38])([CH3:40])[CH3:39])[CH2:7][C:8]([N:10]1[CH2:11][CH2:12][N:13]([C:16]2[CH:21]=[CH:20][C:19]([N:22]3[CH2:26][C@H:25]([CH2:27][O:28][C:29]4[CH:33]=[CH:32][O:31][N:30]=4)[O:24][C:23]3=[O:34])=[CH:18][C:17]=2[F:35])[CH2:14][CH2:15]1)=[O:9]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 69983200HCID 69983200, compound

Product 1

HCID 69982183HCID 69982183, compoundYield 76.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-(4-(4-((3R)-3-Acetoxy-4-trimethylarnmoniobutanoyl)piperazin-1-yl)-3-fluorophenyl)-5(R)-(isoxazol-3-yloxymethyl)oxazolidin-2-one chloride (200 mg, 0.33 mmol) and potassium carbonate (67 mg, 0.49 mmol) were stirred at ambient temperature under nitrogen in MeOH (20 ml) for 5 hours. The mixture was evaporated to dryness, the solid triturated with water, filtered and washed with water (20 ml) to give the desired product (137 mg). MS (ESP): 506 (M+) for C24H33FN5O6;

Workup

  1. customThe mixture was evaporated to dryness
  2. customthe solid triturated with water
  3. filtrationfiltered
  4. washwashed with water (20 ml)

Sources & evidence

ORD record
ord-28f4e5b672ea47b684c7c45cbd08493a
Source dataset
uspto-grants-2003_09
Patent number
US06617339B1

Reaction notes

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