Water → HCID 12097196, compound

HRID 1167606Notes

Reaction equation

HRID 1167606 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:15]=[CH:14][C:6]([C:7]([C:9]2[N:13]=[CH:12][NH:11][N:10]=2)=[O:8])=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:24][N:25]([CH3:30])[S:26](Cl)(=[O:28])=[O:27].O>CN(C=O)C>[CH3:24][N:25]([CH3:30])[S:26]([N:11]1[CH:12]=[N:13][C:9]([C:7](=[O:8])[C:6]2[CH:14]=[CH:15][C:3]([C:2]([F:1])([F:16])[F:17])=[CH:4][CH:5]=2)=[N:10]1)(=[O:28])=[O:27]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 83372Dimethylsulphamoyl chlorideHCID 178519579HCID 178519579, compound

Product 1

HCID 12097196HCID 12097196, compoundYield 69.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.31 g of 3-(4-trifluoromethylbenzoyl)-1,2,4-triazole was dissolved in 3 ml of DMF, 0.21 g of potassium carbonate was added thereto, and then 0.22 g of dimethylsulfamoyl chloride was added at room temperature with stirring. After stirring the reaction mixture for 1.5 hours at room temperature, water was added to precipitate crystals, and the crystals were collected by filtration and washed with diethyl ether. Drying of the mixture under reducing pressure afforded 0.31 g of the titled compound.

Workup

  1. stirringAfter stirring the reaction mixture for 1.5 hours at room temperature
  2. customto precipitate crystals
  3. filtrationthe crystals were collected by filtration
  4. washwashed with diethyl ether
  5. customDrying of the mixture

Sources & evidence

ORD record
ord-96ec70a759d44d79a741ec158574ae2a
Source dataset
uspto-grants-2003_09
Patent number
US06620812B2

Reaction notes

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