HRID1167684

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

HCID83172

Benzyl succinimido carbonate

C12H11NO5

结构：COC(=O)[C@@H](N)CN1C(=O)NC2(CCN(C(=O)OC(C)(C)C)CC2)C1=O

HCID59093808

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](CN1C(=O)NC2(CCN(C(=O)OC(C)(C)C)CC2)C1=O)NC(=O)OCc1ccccc1

HCID86583697

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

PROCEDURE

实验过程

2.08 g (16.1 mmol) of diisopropylethylamine in 25 ml of absolute DMF are added to a solution of 3.14 g (8.48 mmol) of (34.5) and 2.11 g (8.48 mmol) of N-benzyloxycarbonyloxysuccinimide in 80 ml of absolute DMF and the mixture is left to stir at room temperature for 3 h. The solvent is removed in vacuo and the residue is chromatographed through silica gel using heptane/ethyl acetate=6/4. (34.6) is obtained after concentrating the product fractions.

WORKUP

后处理

waitthe mixture is left
customThe solvent is removed in vacuo
customthe residue is chromatographed through silica gel

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b5e918d3c4b84eeb8c68193ec6511333
来源数据集: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06620820B2
来源说明: uspto-grants-2003_09

反应 SMILES

C(N(C(C)C)CC)(C)C.[NH2:10][C@H:11]([C:32]([O:34][CH3:35])=[O:33])[CH2:12][N:13]1[C:17](=[O:18])[C:16]2([CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]2)[NH:15][C:14]1=[O:31].[CH2:36]([O:43][C:44](ON1C(=O)CCC1=O)=[O:45])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>CN(C=O)C>[CH2:36]([O:43][C:44]([NH:10][C@H:11]([C:32]([O:34][CH3:35])=[O:33])[CH2:12][N:13]1[C:17](=[O:18])[C:16]2([CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]2)[NH:15][C:14]1=[O:31])=[O:45])[C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1