Sodium hydride → HCID 10228609, compound

HRID 1167747Notes

Reaction equation

HRID 1167747 reaction equation
Cl[C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][N:27]=1)[C:5]([NH:7][C:8]1[S:9][C:10]2[C:16]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:15][CH:14]=[C:13]([O:23][CH3:24])[C:11]=2[N:12]=1)=[O:6].[H-].[Na+].[OH:30][CH2:31][CH2:32][N:33]1[CH2:37][CH2:36][CH2:35][C:34]1=[O:38]>O1CCOCC1>[CH3:24][O:23][C:13]1[C:11]2[N:12]=[C:8]([NH:7][C:5](=[O:6])[C:4]3[CH:25]=[CH:26][N:27]=[C:2]([O:30][CH2:31][CH2:32][N:33]4[CH2:37][CH2:36][CH2:35][C:34]4=[O:38])[CH:3]=3)[S:9][C:10]=2[C:16]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 769801-(2-Hydroxyethyl)-2-pyrrolidinoneHCID 113156942-Chloro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide

Product 1

HCID 10228609HCID 10228609, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

From 2-chloro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide with sodium hydride and 1-(2-hydroxyethyl)-2-pyrrolidone in dioxane. ES-MS m/e (%): 520 (M+Na+, 47), 498 (M+H+, 100). Analogously to Example 7 there were obtained:

Workup

  1. customAnalogously to Example 7 there were obtained

Sources & evidence

ORD record
ord-ad7df46219f7447b8a8ad273599f51e4
Source dataset
uspto-grants-2003_09
Patent number
US06620811B2

Reaction notes

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