2-Methoxyethanol → HCID 10114404, compound

HRID 1167767Notes

Reaction equation

HRID 1167767 reaction equation
Cl[C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8][C:9]2[S:10][C:11]3[C:17]([N:18]4[CH2:23][CH2:22][O:21][CH2:20][CH2:19]4)=[CH:16][CH:15]=[C:14]([O:24][CH3:25])[C:12]=3[N:13]=2)=[O:7])=[CH:4][N:3]=1.[H-].[Na+].[CH3:30][O:31][CH2:32][CH2:33][OH:34]>O1CCOCC1.CN(C=O)C>[CH3:30][O:31][CH2:32][CH2:33][O:34][C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8][C:9]2[S:10][C:11]3[C:17]([N:18]4[CH2:23][CH2:22][O:21][CH2:20][CH2:19]4)=[CH:16][CH:15]=[C:14]([O:24][CH3:25])[C:12]=3[N:13]=2)=[O:7])=[CH:4][N:3]=1

Participants

6

Reactant 3

HCID 80192-MethoxyethanolHCID 24758Sodium hydrideHCID 22993400HCID 22993400, compound

Product 1

HCID 10114404HCID 10114404, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 312751,4-DioxaneSolvent

Procedure

From 6-chloro-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-nicotinamide with sodium hydride and 2-methoxyethanol in dioxane and DMF. ES-MS m/e (%): 467 (M+Na+, 24), 445 (M+H+, 100).

Sources & evidence

ORD record
ord-3d3ec31a0dd94443a9724e8ef05efca1
Source dataset
uspto-grants-2003_09
Patent number
US06620811B2

Reaction notes

Loading…