2-(Dimethylamino)ethanol → HCID 10195249, compound

HRID 1167790Notes

Reaction equation

HRID 1167790 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][N:27]=1)[C:5]([NH:7][C:8]1[S:9][C:10]2[C:16]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:15][CH:14]=[C:13]([O:23][CH3:24])[C:11]=2[N:12]=1)=[O:6].[H-].[Na+].[CH3:30][N:31]([CH3:35])[CH2:32][CH2:33][OH:34]>O1CCOCC1.CN(C=O)C>[CH3:30][N:31]([CH3:35])[CH2:32][CH2:33][O:34][C:2]1[CH:3]=[C:4]([CH:25]=[CH:26][N:27]=1)[C:5]([NH:7][C:8]1[S:9][C:10]2[C:16]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:15][CH:14]=[C:13]([O:23][CH3:24])[C:11]=2[N:12]=1)=[O:6]

Participants

6

Reactant 3

HCID 79022-(Dimethylamino)ethanolHCID 24758Sodium hydrideHCID 229934292-bromo-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide

Product 1

HCID 10195249HCID 10195249, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 312751,4-DioxaneSolvent

Procedure

From 2-bromo-N-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-isonicotinamide with sodium hydride and 2-dimethylaminoethanol in dioxane and DMF. ES-MS m/e (%): 458 (M+H+, 100).

Sources & evidence

ORD record
ord-662023d2c2ef465fa6f1311115c81edf
Source dataset
uspto-grants-2003_09
Patent number
US06620811B2

Reaction notes

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