4'-Hydroxyacetophenone → 1-[4-(3-Chloropropoxy)phenyl]ethanone

HRID 1167835Notes

Reaction equation

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.Br[CH2:12][CH2:13][CH2:14][Cl:15].C(=O)([O-])[O-].[K+].[K+]>>[Cl:15][CH2:14][CH2:13][CH2:12][O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 74694'-Hydroxyacetophenone

HCID 80061-Bromo-3-chloropropane

HCID 11430Potassium Carbonate

Product 1

HCID 126856131-[4-(3-Chloropropoxy)phenyl]ethanone

Procedure

1-(4-hydroxyphenyl)ethanone, 1-bromo-3-chloropropane and potassium carbonate were processed as described in Example 67B to provide the title compound which was used in the next step without further purification.

Sources & evidence

ORD record: ord-aa657a28360b43b4b4dcbb5b43b067a5
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06620839B2

Reaction notes

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