Sodium Iodide → Methyl 5-amino-6-chloro-2-propylimidazo[1,2-a]pyridine-8-carboxylate

HRID 1168255Notes

Reaction equation

[NH2:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]([Cl:12])=[C:4]([NH2:13])[N:3]=1.Cl[CH2:15][C:16](=O)[CH2:17][CH2:18][CH3:19].[I-].[Na+]>>[NH2:13][C:4]1[N:3]2[CH:15]=[C:16]([CH2:17][CH2:18][CH3:19])[N:1]=[C:2]2[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][C:5]=1[Cl:12]

Participants

Reactant 3

HCID 5238Sodium Iodide

HCID 112864631-Chloropentan-2-one

HCID 12088100Methyl 2,6-Diamino-5-chloronicotinate

Product 1

HCID 22992222Methyl 5-amino-6-chloro-2-propylimidazo[1,2-a]pyridine-8-carboxylate

Procedure

The title compounds were prepared according to the procedure described in the step 2 EXAMPLE 1 (METHOD B) using methyl 2,6-diamino-5-chloro-3-pyridinecarboxylate (EXAMPLE 1, METHOD B, Step 1), 1-chloropentane-2-one (Synthesis, 1987, 2, 188-190) and sodium iodide.

Sources & evidence

ORD record: ord-50c734e175ed49758f7312df5335a31c
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06624162B2

Reaction notes

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