Ethyl Bromide → 3-Ethyl-quinolino[5,6-d]imidazolinone

HRID 1168418Notes

Reaction equation

HRID 1168418 reaction equation
[NH:1]1[C:5]2[C:6]3[CH:7]=[CH:8][CH:9]=[N:10][C:11]=3[CH:12]=[CH:13][C:4]=2[NH:3][C:2]1=[O:14].[H-].[Na+].Br[CH2:18][CH3:19]>>[CH2:18]([N:3]1[C:4]2[CH:13]=[CH:12][C:11]3[N:10]=[CH:9][CH:8]=[CH:7][C:6]=3[C:5]=2[NH:1][C:2]1=[O:14])[CH3:19]

Participants

4

Reactant 3

HCID 6332Ethyl BromideHCID 24758Sodium hydrideHCID 14086727HCID 14086727, compound

Product 1

HCID 698658863-Ethyl-quinolino[5,6-d]imidazolinone

Procedure

3-Ethyl-quinolino[5,6-d]imidazolinone (1f) was prepared analogously by treatment of quinolino[5,6-d]imidazolinone with sodium hydride (1.1 eq.) and bromoethane (1.1 eq.), successively. Yield after column-chromatographic workup: 12%. Mp. 258-259° C.

Workup

  1. customYield after column-chromatographic workup

Sources & evidence

ORD record
ord-6b5b743551c4426bbc110038e89212ae
Source dataset
uspto-grants-2003_09
Patent number
US06624186B2

Reaction notes

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