Diethyl (ethoxymethylene)malonate → HCID 12083030, compound

HRID 1168505Notes

Reaction equation

HRID 1168505 reaction equation
[CH3:1][C:2]1([CH3:11])[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3]1.C(O[CH:15]=[C:16]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:17]([O:19][CH2:20][CH3:21])=[O:18])C>>[CH3:1][C:2]1([CH3:11])[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[CH:15]=[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:22]([O:24][CH2:25][CH3:26])=[O:23]

Participants

3

Reactant 2

HCID 6871Diethyl (ethoxymethylene)malonateHCID 124373022,2-diMethyl-2,3-dihydro-1H-indole

Product 1

HCID 12083030HCID 12083030, compound

Conditions

Temperature
105 °C

Procedure

A mixture of 2,2-dimethylindoline (1.47 g) and diethyl ethoxymethylenemalonate (2.0 ml) is heated to 105° C. for 17 hours to afford the title compound as a pale yellow oil. Physical characteristics: 1H NMR (CDCl3) δ7.76, 7.18, 7.12, 6.97, 6.74, 4.24, 3.16, 1.50, 1.34.

Sources & evidence

ORD record
ord-62ec539d348e47e59aa4cc5914ae4f11
Source dataset
uspto-grants-2003_09
Patent number
US06624159B2

Reaction notes

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