Sodium Chloride → HCID 22989739, compound

Under a nitrogen atmosphere, a solution of 3-(dimethylamino)phenol (3.50 g, 25.51 mmol) in DMF (30 mL) was slowly added over 10 min to a cold (0-5° C.), stirring slurry of sodium hydride (0.80 g of an 80% dispersion in mineral oil, 26.79 mmol) in DMF (40 mL). The mixture was allowed to warm to ambient temperature and further stirred for 1.25 h. The resulting brown mixture was cooled to 0-5C. To this slurry was added drop-wise over 5 min, 1-chloro-3-iodopropane (6.26 g, 30.62 mmol). The resulting reddish brown mixture was stirred at ambient temperature for 4.25 h. Cold water (35 mL) was carefully added, followed by saturated NaCl solution (35 mL). The resulting mixture was extracted with ether (4×50 mL). The combined dull-yellow ether extracts were dried (Na2SO4), filtered, and concentrated by rotary evaporation producing a light-brown oil (5.65 g).

1. temperatureThe resulting brown mixture was cooled to 0-5C
2. additionTo this slurry was added drop-wise over 5 min
3. stirringThe resulting reddish brown mixture was stirred at ambient temperature for 4.25 h
4. extractionThe resulting mixture was extracted with ether (4×50 mL)
5. dry with materialThe combined dull-yellow ether extracts were dried (Na2SO4)
6. filtrationfiltered
7. concentrationconcentrated by rotary evaporation

ORD record

ord-98b98d6cddf64eaab9f28a16384bc8ef

Source dataset

uspto-grants-2003_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06627648B1