Sodium hydride → 6-[6-[4-(Diphenylmethoxy)piperidino]hexyloxy]-7-methyl[1,2,4]triazolo[1,5-b]pyridazine Hydrochloride

HRID 1169050Notes

Reaction equation

HRID 1169050 reaction equation
[H-].[Na+].[C:3]1([CH:9]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[O:10][CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][OH:23])[CH2:13][CH2:12]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Cl:30][C:31]1[C:32]([CH3:40])=[CH:33][C:34]2[N:35]([N:37]=[CH:38][N:39]=2)[N:36]=1>O1CCCC1>[ClH:30].[C:3]1([CH:9]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[O:10][CH:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][O:23][C:31]3[C:32]([CH3:40])=[CH:33][C:34]4[N:35]([N:37]=[CH:38][N:39]=4)[N:36]=3)[CH2:13][CH2:12]2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 118051586-Chloro-7-methyl-[1,2,4]triazolo[1,5-b]pyridazineHCID 229893784-(Diphenylmethoxy)-1-piperidinehexanol

Product 1

HCID 229894326-[6-[4-(Diphenylmethoxy)piperidino]hexyloxy]-7-methyl[1,2,4]triazolo[1,5-b]pyridazine HydrochlorideYield 38.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

160 mg of 60% sodium hydride in oil was suspended in 20 ml of tetrahydrofuran; 1.24 g of 4-(diphenylmethoxy)-1-piperidinehexanol was added, followed by heating and refluxing for 1 hour. After cooling, 570 mg of 6-chloro-7-methyl[1,2,4]triazolo[1,5-b]pyridazine was added, followed by heating and refluxing for 1 hour. After cooling, ice water was added, followed by extraction with ethyl acetate; the extract was washed with saturated saline, dried over magnesium sulfate and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography and eluted with ethyl acetate-methanol (10:1). The desired fraction was collected and dissolved in 5 ml of ethyl acetate; 0.54 ml of a 4 N hydrogen chloride solution in ethyl acetate was added; the crystal precipitated was collected by filtration, washed with ethyl ether and dried to yield 0.70 g of the title compound.

Workup

  1. temperatureby heating
  2. temperaturerefluxing for 1 hour
  3. temperatureAfter cooling
  4. temperatureby heating
  5. temperaturerefluxing for 1 hour
  6. temperatureAfter cooling
  7. extractionfollowed by extraction with ethyl acetate
  8. washthe extract was washed with saturated saline
  9. dry with materialdried over magnesium sulfate
  10. concentrationconcentrated under reduced pressure
  11. washeluted with ethyl acetate-methanol (10:1)
  12. customThe desired fraction was collected
  13. dissolutiondissolved in 5 ml of ethyl acetate
  14. addition0.54 ml of a 4 N hydrogen chloride solution in ethyl acetate was added
  15. customthe crystal precipitated
  16. filtrationwas collected by filtration
  17. washwashed with ethyl ether
  18. customdried

Sources & evidence

ORD record
ord-424b1bc115ab40ab969141cc0b6eb39d
Source dataset
uspto-grants-2003_09
Patent number
US06627630B1

Reaction notes

Loading…