反应详情

To methyl 2-benzyloxy-6,7-dihydro-5H-benzocycloheptene-8-carboxylate (2.28 g, 7.39 mmol) suspended in methanol (25 ml) was added a 1N aqueous solution of sodium hydroxide (23 ml), and the resulting mixture was stirred at room temperature for 13 hours. In order to complete the reaction, tetrahydrofuran (25 ml) was added, and the resulting mixture was stirred at 60° C. for 2 hours. The reaction mixture was mixed with 1 N hydrochloric acid (23 ml) at room temperature, was concentrated under reduced pressure and was mixed with water, and an insoluble material was collected by filtration. The insoluble material was washed with water and was dried under reduced pressure to obtain 2-benzyloxy-6,7-dihydro-5H-benzocycloheptene-8-carboxylic acid (2.09 g, 7.10 mmol, 96%).

1. additionwas added
2. stirringthe resulting mixture was stirred at 60° C. for 2 hours
3. concentrationwas concentrated under reduced pressure
4. additionwas mixed with water
5. filtrationan insoluble material was collected by filtration
6. washThe insoluble material was washed with water
7. customwas dried under reduced pressure