Potassium Carbonate → HCID 22990010, compound

To methyl 2-hydroxy-6,7-dihydro-5H-benzocycloheptene-8-carboxylate (327 mg, 1.50 mmol) dissolved in DMF (6 ml) were added potassium carbonate (415 mg, 3.00 mmol) and 2,6-difluorobenzyl chloride (268 mg, 1.65 mmol), and the resulting mixture was stirred at room temperature for 24 hours. The reaction mixture was concentrated under reduced pressure, ethyl acetate (40 ml) was added to the residue and the resulting mixture was washed with water (5 ml×2) and an aqueous saturated solution of sodium chloride (5 ml). The organic layer was dried with anhydrous magnesium sulfate and was then concentrated under reduced pressure, and the residue was subjected to column chromatography (silica gel: 15 g, ethyl acetate/hexane=1/25). The objective fractions were concentrated under reduced pressure to obtain methyl 2-(2,6-difluorobenzyloxy)-6,7-dihydro-5H-benzocycloheptene-8-carboxylate (507 mg, 1.47 mmol, 98%).

1. concentrationThe reaction mixture was concentrated under reduced pressure, ethyl acetate (40 ml)
2. additionwas added to the residue
3. washthe resulting mixture was washed with water (5 ml×2)
4. dry with materialThe organic layer was dried with anhydrous magnesium sulfate
5. concentrationwas then concentrated under reduced pressure
6. concentrationThe objective fractions were concentrated under reduced pressure

ORD record

ord-91ba2222cb1a4f68a325af96828bc5b1

Source dataset

uspto-grants-2003_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06627651B1