Stannous chloride dihydrate → HCID 42605101, compound

HRID 1169577Notes

Reaction equation

HRID 1169577 reaction equation
[C:1]([C:3]1[C:4]([O:21][S:22]([C:25]([F:28])([F:27])[F:26])(=[O:24])=[O:23])=[N:5][C:6]([CH:18]2[CH2:20][CH2:19]2)=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1)#[N:2].O.O.[Sn](Cl)Cl>CCO>[NH2:15][C:12]1[CH:11]=[CH:10][C:9]([C:8]2[CH:7]=[C:6]([CH:18]3[CH2:19][CH2:20]3)[N:5]=[C:4]([O:21][S:22]([C:25]([F:27])([F:28])[F:26])(=[O:24])=[O:23])[C:3]=2[C:1]#[N:2])=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 59550643HCID 59550643, compound

Product 1

HCID 42605101HCID 42605101, compoundYield 86.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In analogy to GP 3, reaction of 1.49 g trifluoromethanesulphonic acid 3-cyano-6-cyclopropyl-4-(4-nitro-phenyl)-pyridin-2-yl ester (3.6 mmol, 1 eq.) with 4.1 g tin(II) chloride dihydrate (18.19 mmol, 5 eq.) in 20 mL EtOH yielded 1.2 g of the desired aniline (3.1 mmol, 86% yield).

Sources & evidence

ORD record
ord-f99dbf05da134c52b91b72a6836e4a16
Source dataset
uspto-grants-2010_11
Patent number
US07825114B2

Reaction notes

Loading…