Hydrazine hydrate (1:1) → HCID 178509216, compound

HRID 1169579Notes

Reaction equation

HRID 1169579 reaction equation
[C:1]([C:3]1[C:4](OS(C(F)(F)F)(=O)=O)=[N:5][C:6]([CH:26]2[CH2:28][CH2:27]2)=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[F:25])=O)=[CH:11][CH:10]=1)#[N:2].[OH2:37].[NH2:38][NH2:39]>C(O)CC>[NH2:2][C:1]1[C:3]2[C:4](=[N:5][C:6]([CH:26]3[CH2:28][CH2:27]3)=[CH:7][C:8]=2[C:9]2[CH:10]=[CH:11][C:12]([NH:15][C:16]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[F:25])=[O:37])=[CH:13][CH:14]=2)[NH:39][N:38]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 42605083HCID 42605083, compound

Product 1

HCID 178509216HCID 178509216, compoundYield 26%

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

In analogy to the GP 5, reaction of 175 mg trifluoromethanesulphonic acid 3-cyano-6-cyclopropyl-4-{4-[3-(2-fluoro-phenyl)-ureido]-phenyl}-pyridin-2-yl ester (0.336 mmol) with 62 μl 80% hydrazine hydrate in 1-propanol yielded 35 mg product (0.087 mmol, 26% yield).

Sources & evidence

ORD record
ord-c78e5b8102d14f3191e48e7d7edd776b
Source dataset
uspto-grants-2010_11
Patent number
US07825114B2

Reaction notes

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