反应详情

温度

50 °C

To a solution of 3-hydroxybenzaldehyde (5.0 g) in acetone (120 mL), potassium carbonate (8.5 g) and methoxymethyl chloride (4.0 g) were added, followed by stirring at 50° C. for 6 hours. The reaction mixture was concentrated and water was added thereto, followed by extraction with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, dried and concentrated. The residue thus obtained was purified by silica gel column chromatography (hexane:ethyl acetate=10:1) to thereby give the title compound (6.0 g) having the following physical properties.

1. concentrationThe reaction mixture was concentrated
2. additionwater was added
3. extractionfollowed by extraction with ethyl acetate
4. washThe organic layer was washed with a saturated aqueous sodium chloride solution
5. customdried
6. concentrationconcentrated
7. customThe residue thus obtained
8. customwas purified by silica gel column chromatography (hexane:ethyl acetate=10:1)