HCID 86595327, compound → 5,5-Dimethyl-3-{4-[(trifluoromethyl)sulfanyl]phenyl}imidazolidine-2,4-dione
Reaction equation
[CH3:1][C:2]([NH:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][C:14]([S:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=1)=[O:9])([CH3:6])[C:3]([O-])=[O:4]>Cl.O1CCOCC1>[CH3:1][C:2]1([CH3:6])[NH:7][C:8](=[O:9])[N:10]([C:11]2[CH:16]=[CH:15][C:14]([S:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)[C:3]1=[O:4]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Conditions
- Temperature
- 4 °C
Procedure
30 g of 2-methyl-2-[3-(4-trifluoromethylsulfanylphenyl)ureido]propionate 3 are dissolved in a mixture of 225 ml of 3 N HCl and 230 ml of dioxane, refluxed for 6 hours and, after cooling to 4° C., the product 5,5-dimethyl-3-(4-trifluoromethylsulfanylphenyl)-imidazolidine-2,4-dione is isolated in the form of white crystals (24.14 g).
Workup
- temperaturerefluxed for 6 hours
Sources & evidence
- ORD record
- ord-cc661fa293414183822215cb210bc113
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07825115B2
Reaction notes
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