反应详情

2,4-Dichloro-5-bromopyrimidine (7.98 g, 35 mmol) is dissolved in DMF (35 ml) and Cs2CO3 (11.4 g, 35 mmol) and 3-hydroxy-propionic acid tert-butyl-ester (5.12 g, 35 mmol) are added. The reaction mixture is stirred for 5 h at rt. The reaction mixture is diluted with brine and the extracted with ethyl acetate (3×). The organic layers are washed with brine, dried over sodiumsulfat and evaporated to dryness. The crude product is used for the following reaction without any further purification.

1. extractionthe extracted with ethyl acetate (3×)
2. washThe organic layers are washed with brine
3. dry with materialdried over sodiumsulfat
4. customevaporated to dryness
5. customThe crude product is used for the following reaction without any further purification