3,4-Diaminotoluene → 4-Hydroxy-3-(6-methyl-1H-benzoimidazol-2-yl)-1H-[1,7]naphthyridin-2-one

HRID 1170011노트

반응식

HRID 1170011 반응식
CO[C:3]([CH2:5][C:6]([NH:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][C:14]=1[C:15]([OH:17])=O)=[O:7])=O.[CH3:18][C:19]1[CH:24]=[CH:23][C:22]([NH2:25])=[C:21]([NH2:26])[CH:20]=1>>[OH:17][C:15]1[C:14]2[C:9](=[CH:10][N:11]=[CH:12][CH:13]=2)[NH:8][C:6](=[O:7])[C:5]=1[C:3]1[NH:26][C:21]2[CH:20]=[C:19]([CH3:18])[CH:24]=[CH:23][C:22]=2[N:25]=1

참가 물질

3

반응물 2

HCID 103323,4-DiaminotolueneHCID 129887813-[2-(Methoxycarbonyl)acetylamino]pyridine-4-carboxylic acid

생성물 1

HCID 1355181534-Hydroxy-3-(6-methyl-1H-benzoimidazol-2-yl)-1H-[1,7]naphthyridin-2-one

실험 절차

The title compound was synthesized as described in Example 50 using 3-[2-(methoxycarbonyl)acetylamino]-pyridine-4-carboxylic acid and 4-methyl-1,2-phenylenediamine. The crude product was purified by reversed-phase HPLC (DMSO/5% TFA). LC/MS m/z 293.3 (MH+), Rt 1.99 minutes.

후처리

  1. customThe crude product was purified by reversed-phase HPLC (DMSO/5% TFA)

출처 및 근거

ORD 기록
ord-60f72c8ccba74b0aa56142d5bf7e33d6
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07825132B2

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