3-Bromopyridine → (2-Methoxy-benzyl)-[5-((E)-2-pyridin-3-yl-vinyl)-quinolin-2-yl]-amine

HRID 1170082Notes

Reaction equation

HRID 1170082 reaction equation
[CH3:1][O:2][C:3]1[CH:22]=[CH:21][CH:20]=[CH:19][C:4]=1[CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2[CH:17]=[CH2:18])[N:8]=1.Br[C:24]1[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=1>>[CH3:1][O:2][C:3]1[CH:22]=[CH:21][CH:20]=[CH:19][C:4]=1[CH2:5][NH:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][C:13]=2/[CH:17]=[CH:18]/[C:24]2[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=2)[N:8]=1

Participants

3

Reactant 2

HCID 122863-BromopyridineHCID 44218150(2-Methoxy-benzyl)-(5-vinyl-quinolin-2-yl)-amine

Product 1

HCID 68436701(2-Methoxy-benzyl)-[5-((E)-2-pyridin-3-yl-vinyl)-quinolin-2-yl]-amine

Procedure

(2-Methoxy-benzyl)-(5-vinyl-quinolin-2-yl)-amine (150 mg, 0.517 mmol) was reacted with 3-bromopyridine (108 mg, 0.688 mmol) as described in example 2 step B. The title compound was obtained as a light brown solid (93 mg, 49%), MS: m/e=368.1 (M+H+).

Sources & evidence

ORD record
ord-e1edf8d469684634a5a753d589306366
Source dataset
uspto-grants-2010_11
Patent number
US07825253B2

Reaction notes

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