反应详情

3,3-bis (N-CBz-L-valyloxymethyl)-propionic acid (3 g, 5 mmole) was dissolved in dioxane (20 ml). To the solution was added tetrabutylammonium hydroxide aqueous solution (40%, 3.11 ml, 4.8 mmole). The solution was dried in vacuo, and it was coevaporated with toluene several times. The residue was dissolved in methylene chloride (15 ml) and then chloroiodomethane (7.3 ml, 100 mmole) was added to the solution. The reaction solution was refluxed for 18 hr and then evaporated and the product was isolated with silica gel column chromatography. 900 mg.

1. customThe solution was dried in vacuo, and it
2. dissolutionThe residue was dissolved in methylene chloride (15 ml)
3. temperatureThe reaction solution was refluxed for 18 hr
4. customevaporated
5. customthe product was isolated with silica gel column chromatography