Oxalic acid dihydrate → 4,5,6,7-tetrahydro-4-(2-(morpholin-4-yl)ethyl)-1-phenyl-1H-indazole oxalate

HRID 1170846Notes

Reaction equation

HRID 1170846 reaction equation
[C:1]([C:4]([OH:6])=[O:5])([OH:3])=[O:2].O.O.[N:9]1([CH2:15][CH2:16][CH:17]2[CH2:25][CH2:24][CH2:23][C:22]3[N:21]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[N:20]=[CH:19][C:18]2=3)[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>CC(C)=O>[C:4]([OH:6])(=[O:5])[C:1]([OH:3])=[O:2].[N:9]1([CH2:15][CH2:16][CH:17]2[CH2:25][CH2:24][CH2:23][C:22]3[N:21]([C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)[N:20]=[CH:19][C:18]2=3)[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 61373Oxalic acid dihydrateHCID 115314514,5,6,7-tetrahydro-4-(2-(morpholin-4-yl)ethyl)-1-phenyl-1H-indazole

Product 1

HCID 115314504,5,6,7-tetrahydro-4-(2-(morpholin-4-yl)ethyl)-1-phenyl-1H-indazole oxalateYield 65%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

HO2CCO2H.2H2O (156 mg, 1.23 mmol) is added to a solution of 4,5,6,7-tetrahydro-4-(2-(morpholin-4-yl)ethyl)-1-phenyl-1H-indazole (380 mg, 1.22 mmol) in 4 mL of acetone giving 4,5,6,7-tetrahydro-4-(2-(morpholin-4-yl)ethyl)-1-phenyl-1H-indazole oxalate (318 mg, 0.79 mmol, 65%, white solid).

Sources & evidence

ORD record
ord-da96b50949ab40a1b732a5ab3f1c5a26
Source dataset
uspto-grants-2010_11
Patent number
US07829559B2

Reaction notes

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