Hydrochloric Acid → HCID 178478838, compound

HRID 1171047Notes

Reaction equation

HRID 1171047 reaction equation
[ClH:1].C(OC([NH:9][C:10]([NH:19][O:20][CH2:21][CH2:22][NH2:23])=[N:11]C(OC(C)(C)C)=O)=O)(C)(C)C>>[ClH:1].[ClH:1].[NH2:23][CH2:22][CH2:21][O:20][NH:19][C:10]([NH2:11])=[NH:9]

Participants

3

Reactant 2

HCID 313Hydrochloric Acid2×HCID 178454317HCID 178454317, compound

Product 1

HCID 178478838HCID 178478838, compound

Procedure

The HCl salt of ({[(tert-butoxycarbonyl)amino-(tert-butoxycarbonyl)iminomethyl]aminooxy}ethyl)amine (90.5 mg, 255 μmol) (WO 2004/091613 A2) was treated with 12 M HCl (aq) (210 μL, 2.5 mmol) in one portion at rt, and was then stirred at rt for 20 min. The resulting thick white slurry was concentrated under rotary evaporation at rt, and the residue was taken up in toluene (3×3 mL) with repeated rotary evaporation and high vacuum to yield the title compound as an off-white powder (52.9 mg, quantitative yield).

Workup

  1. concentrationThe resulting thick white slurry was concentrated under rotary evaporation at rt
  2. customevaporation and high vacuum

Sources & evidence

ORD record
ord-37279ef85a114019a8378113638ad5df
Source dataset
uspto-grants-2010_11
Patent number
US07829584B2

Reaction notes

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