反应详情

Treat a solution of 4-[(R)-3-(4-Benzyloxy-2,6-dichloro-benzyl)-2-oxo-pyrrolidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester (Preparation 13) (2.2 g, 4.1 mmol) in EtOAc (50 mL) with Palladium Hydroxide on carbon (0.1 g). Purge the solution with Hydrogen and stir the reaction overnight under 1 atm of hydrogen. Filter the reaction through celite to remove the catalyst. Remove the solvent to afford 1.6 g (87%) of desired product. MS (m/e): 441 (M−1).

1. customPurge the solution with Hydrogen
2. customthe reaction overnight under 1 atm of hydrogen
3. filtrationFilter
4. customthe reaction through celite
5. customto remove the catalyst
6. customRemove the solvent