反应详情

To an N,N-dimethylformamide (20 mL) solution of 2-bromomethyl-5-iodo-benzofuran (270 mg, 0.801 mmol) and phenol (113 mg, 1.2 mmol) was added potassium carbonate (332 mg, 2.4 mmol). This mixture was stirred at room temperature for 14 hours. The reaction mixture was poured into sat. NaCl and extracted with ethyl acetate. The organic layer was separated and dried over anhydrous magnesium sulfate followed by concentrating under a reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=7:1) to obtain the title compound (251 mg, 90%).

1. extractionextracted with ethyl acetate
2. customThe organic layer was separated
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationby concentrating under a reduced pressure
5. customThe resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=7:1)