2-Methoxyethylamine → HCID 59553066, compound

HRID 1171325Notes

Reaction equation

HRID 1171325 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[CH3:38][O:39][CH2:40][CH2:41][NH2:42]>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([NH:42][CH2:41][CH2:40][O:39][CH3:38])[N:20]=2)=[CH:10][CH:9]=1)=[O:6]

Participants

3

Reactant 2

HCID 80182-MethoxyethylamineHCID 667379693-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide

Product 1

HCID 59553066HCID 59553066, compound

Procedure

Compound is prepared from 3-fluoro-N-[4-(2-methanesulfonyl-pyrimidin-4-yloxy)-naphthalen-1-yl]-5-piperidin-1-yl-benzamide and 2-methoxyethylamine according to conditions described in general procedure C. Mp: 87-88° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.60-1.63 (m, 6 H), 3.00-3.38 (m, 1 H), 6.20-6.40 (m, 1 H), 6.99 (d, J=12.4 Hz, 1 H), 7.09-7.18 (m, 2 H), 7.40 (d, J=7.7 Hz, 1 H), 7.46 (s, 1 H), 7.55-7.62 (m, 3 H), 7.82 (d, J=8.0 Hz, 1 H), 7.99 (d, J=8.0 Hz, 1 H), 8.23 (s, 1 H), 10.43 (s, 1 H).

Sources & evidence

ORD record
ord-6b32d509c2e844128c68345bd367f8fd
Source dataset
uspto-grants-2010_11
Patent number
US07829560B2

Reaction notes

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