反应详情

温度

150 °C

A solution of 4-bromofuran-2-carboxylic acid (380 mg, 2 mmol), phenylboronic acid (488 mg, 4 mmol) in DMF (3 ml) was place in a microwave reaction tube and treated with a 2 M K3PO4(aq) (2 ml, 4 mmol). The solution was purged with nitrogen for 10 minutes before adding Pd(PPh3)4 (1.5 mg) catalyst. The mixture was again purged with nitrogen for 5 minutes before the reaction tube was sealed. The mixture was heated in a microwave oven at 150° C. for 30 minutes. The reaction mixture was filtered and the filtrate poured into 1N HCl (100 ml) with stirring. The precipitate was filtered and air-dried to give 190 mg of 4-phenylfuran-2-carboxylic acid. MS (ES−) found: (M−H)−=187.07.

1. customin a microwave reaction tube
2. customThe solution was purged with nitrogen for 10 minutes
3. additionbefore adding Pd(PPh3)4 (1.5 mg) catalyst
4. customThe mixture was again purged with nitrogen for 5 minutes before the reaction tube
5. customwas sealed
6. filtrationThe reaction mixture was filtered
7. additionthe filtrate poured into 1N HCl (100 ml)
8. filtrationThe precipitate was filtered
9. customair-dried