Hydrochloric Acid → HCID 86609441, compound

HRID 1171692Notes

Reaction equation

HRID 1171692 reaction equation
FC(F)(F)C(O)=O.[C:8]([S:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14]/[C:13]/1=[CH:18]\[C:19]1[N:23]([CH2:24][C:25]([O:27][CH3:28])=[O:26])[N:22]=[N:21][CH:20]=1)(=[O:10])[CH3:9].Br[CH:30]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[F:42])[C:31]([CH:33]1[CH2:35][CH2:34]1)=[O:32].[ClH:43]>C(N(CC)CC)C>[ClH:43].[C:8]([S:11][CH:12]1[CH2:17][CH2:16][N:15]([CH:30]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=2[F:42])[C:31]([CH:33]2[CH2:34][CH2:35]2)=[O:32])[CH2:14]/[C:13]/1=[CH:18]\[C:19]1[N:23]([CH2:24][C:25]([O:27][CH3:28])=[O:26])[N:22]=[N:21][CH:20]=1)(=[O:10])[CH3:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 234358712-Bromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-oneHCID 87566618HCID 87566618, compound

Product 1

HCID 86609441HCID 86609441, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Following a procedure similar to that described in Example 150-(g), (E)-4-(acetylsulfanyl)-3-{[1-(methoxycarbonylmethyl)-1H-1,2,3-triazol-5-yl]methylidene}piperidine hydrogen trifluoroacetate (1.06 g) was subjected to the reaction with 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone and triethylamine and the free base that was obtained by silica gel chromatography was similarly treated with hydrogen chloride to yield the title compound (650 mg, yield: 50%) as a pale yellow amorphous solid.

Workup

  1. customthe free base that was obtained by silica gel chromatography

Sources & evidence

ORD record
ord-6f2d24390ed34c3b86bdbb59f0c2867d
Source dataset
uspto-grants-2010_11
Patent number
US07829580B2

Reaction notes

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