反应详情

To tetrahydrofuran (THF, 500 ml) was added carefully lithium aluminium hydride (7.3 g) with stirring. The resulting mixture was stirred at 0° C., to which was added dropwise a solution of ethyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate (50.0 g) in THF (500 ml). The resulting mixture was stirred at room temperature for 30 minutes, and the reaction was stopped by careful addition of sodium sulfate decahydrate. The slurry mixture was stirred at room temperature for 2 hours further, filtered to remove solids, and the filtrate was concentrated in vacuo to afford [1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl]methanol (39.51 g, yield: 94%).

1. stirringThe resulting mixture was stirred at 0° C., to which
2. stirringThe resulting mixture was stirred at room temperature for 30 minutes
3. stirringThe slurry mixture was stirred at room temperature for 2 hours further
4. filtrationfiltered
5. customto remove solids
6. concentrationthe filtrate was concentrated in vacuo